2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-128742R
    Thiamine monophosphate chloride dihydrate (Standard) 273724-21-3
    Thiamine monophosphate (chloride) (dihydrate) (Standard) is an analytical standard for Thiamine monophosphate (chloride) (dihydrate). This product is intended for use in research and analytical applications. Thiamine monophosphate chloride dehydrate is a source of Vitamin B1 (HY-A0100). Thiamine monophosphate chloride involves being absorbed and converted to thiamine in the body. Thiamine monophosphate chloride is mainly used in the research of food supplements as a vitaminB1 source to meet the nutritional needs of the body.
    Thiamine monophosphate chloride dihydrate (Standard)
  • HY-128743R
    12-Hydroxydodecanoic acid (Standard) 505-95-3
    Methyl isoeugenol (Standard) is the analytical standard of Methyl isoeugenol. This product is intended for research and analytical applications. Methyl isoeugenol (MIE) is a natural food flavour that can be isolated from Pimenta pseudocaryophyllus leaf. Methyl isoeugenol shows anxiolytic and antidepressant like effects. Methyl isoeugenol is orally active.
    12-Hydroxydodecanoic acid (Standard)
  • HY-128746R
    2,6-Diaminoheptanedioic acid (Standard) 583-93-7
    2,6-Diaminoheptanedioic acid (Standard) is the analytical standard of 2,6-Diaminoheptanedioic acid. This product is intended for research and analytical applications. 2,6-Diaminoheptanedioic acid is an organic reagent with a multifunctional group and can be used in organic synthesis[1].
    2,6-Diaminoheptanedioic acid (Standard)
  • HY-128746S
    2,6-Diaminoheptanedioic acid-13C7,15N2 98%
    2,6-Diaminoheptanedioic acid-13C7,15N2 is 13C and 15N-labeled 2,6-Diaminoheptanedioic acid (HY-128746). 2,6-Diaminoheptanedioic acid is an endogenous metabolite.
    2,6-Diaminoheptanedioic acid-13C7,15N2
  • HY-128753R
    D-Lyxose (Standard) 1114-34-7
    D-Lyxose (Standard) is the analytical standard of D-Lyxose. This product is intended for research and analytical applications. D-Lyxose is an endogenous metabolite.
    D-Lyxose (Standard)
  • HY-128854S
    Dimethyl biphenyl-4,4'-dicarboxylate-d8 1219803-50-5 98%
    Dimethyl biphenyl-4,4'-dicarboxylate-d8 is the deuterium labeled Dimethyl biphenyl-4,4'-dicarboxylate. Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) is a hepatoprotectant obtained from Schizandra fructus and may induce a signal transduction similar to that associated with IFN.
    Dimethyl biphenyl-4,4'-dicarboxylate-d8
  • HY-128895A
    KL1333 hydrochloride 1800406-26-1 98%
    KL1333 hydrochloride is an orally active NAD+ modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD+ levels through NADH oxidation. Elevated NAD+ levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures.
    KL1333 hydrochloride
  • HY-129143R
    Delphinidin-3-sambubioside chloride (Standard) 53158-73-9
    Delphinidin-3-sambubioside (chloride) (Standard) is the analytical standard of Delphinidin-3-sambubioside (chloride). This product is intended for research and analytical applications. Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L..
    Delphinidin-3-sambubioside chloride (Standard)
  • HY-129380R
    Fructosyl-lysine (Standard) 21291-40-7
    Diethylene glycol (Standard) is the analytical standard of Diethylene glycol. This product is intended for research and analytical applications. 2,2'-Oxybis(ethan-1-ol) (DIETHYLENE GLYCOL) has excellent solubility and reactivity in certain chemical reactions and can help accelerate the activation of certain reactants. In addition, it is widely used in the production process of pigments, resins and other chemicals. Although the compound has no direct medical application, it has wide applications in chemical research and industrial production.
    Fructosyl-lysine (Standard)
  • HY-129566R
    Withanolide B (Standard) 56973-41-2
    Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects.
    Withanolide B (Standard)
  • HY-129736A
    P32/98 136259-20-6 98%
    P32/98 a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model.
    P32/98
  • HY-130237R
    Cinnamtannin B-1 (Standard) 88082-60-4
    Cinnamtannin B-1 (Standard) is the analytical standard of Cinnamtannin B-1. This product is intended for research and analytical applications. Cinnamtannin B-1 is a anthocyanidin. Cinnamtannin B-1 inhibits the osteoclast formation by inhibiting NF-kB signaling pathway and ROS generation. Cinnamtannin B-1 exhibits antioxidant, anti-inflammatory, antitumor and anti-platelet aggregation activities. Cinnamtannin B-1 is orally active.
    Cinnamtannin B-1 (Standard)
  • HY-130245A
    (R,R)-PCSK9 degrader 1 2216703-12-5 98%
    (R,R)-PCSK9 degrader 1 is the isomer of PCSK9 degrader 1 (HY-130245). PCSK9 degrader 1 (Compound 16) is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9 with a Ki of 107 nM. PCSK9 degrader 1 can involve in a protein-protein interaction with the low-density lipoprotein (LDL) receptor.
    (R,R)-PCSK9 degrader 1
  • HY-130310B
    (±)11-HEDE 5598-37-8 98%
    (±)11-HEDE is a racemic mixture of the monohydroxy fatty acids 11(S)-HEDE and 11(R)-HEDE. 11-HEDE is formed from eicosadienoic acid by cyclooxygenase (COX) and in macrophages.
    (±)11-HEDE
  • HY-130319A
    9-HEPE 286390-03-2 98%
    9-HEPE, a oxidation product of Eicosapentaenoic acid, is a racemic mixture of 9(R)-HEPE and 9(S)-HEPE. 9-HEPE induces fatty acid oxidation, adipogenesis, and glucose uptake via activation of PPARs in vivo.
    9-HEPE
  • HY-131103R
    Phenylethanolamine A (Standard) 1346746-81-3
    Phenylethanolamine A (Standard) is the analytical standard of Phenylethanolamine A. This product is intended for research and analytical applications. Phenylethanolamine A acts as a β-adrenergic agonist. Phenylethanolamine A is a byproduct during the Ractopamine synthesis process.
    Phenylethanolamine A (Standard)
  • HY-131103S
    Phenylethanolamine A-d3 2507994-61-6
    Phenylethanolamine A-d3 is a deuterium labeled Phenylethanolamine A. Phenylethanolamine A acts as a β-adrenergic agonist. Phenylethanolamine A is a byproduct during the Ractopamine synthesis process.
    Phenylethanolamine A-d3
  • HY-131485A
    3-Acetylpyridine adenine dinucleotide, 95% 86-08-8 98%
    3-Acetylpyridine adenine dinucleotide, 95% (3-APAD, 95%)is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 95% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite.
    3-Acetylpyridine adenine dinucleotide, 95%
  • HY-131504A
    Valienamine 38231-86-6 98%
    Valienamine is the alpha-glucosidase inhibitor. Valienamine is the key functional component of many natural glycosidase inhibitors including the crop protectant validamycin A and the antidiabetic agent acarbose.
    Valienamine
  • HY-131515R
    Tri-Salicylic acid (Standard) 85531-17-5
    Tri-Salicylic acid (Standard) is the analytical standard of Tri-Salicylic acid (HY-131515). This product is intended for research and analytical applications. Tri-Salicylic acid (Compound III) is a compound with similar properties to salicylic acid. Tri-Salicylic acid can be used in the research of inflammation, obesity, diabetes, and cardiovascular disease.
    Tri-Salicylic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity